The Institute for Restorative Health will encompass not only the state-of-the-art laboratories and equipment required by scientists, but also the exam and treatment rooms required by physicians to apply it.
Exploring the mechanisms by which vascular endothelial cells promote hematopoietic stem cell emergence, maintenance, and regeneration to develop therapeutic modalities to repair injured and aged hematopoietic systems.
Dr. Korngold’s lab focuses on improvement of hematopoietic stem cell transplantation. In particular, we are interested in control of graft-versus-host disease development following allogeneic transplantation while enhancing graft-versus-tumor responses that can prevent a relapse of malignant disease. We are also focused on the utilization of T cell repertoire analysis as an indicator of outcomes post-transplant and the analysis of immune cell subsets to determine the effects of different immunotherapies on anti-tumor responses.
Dr. Zhao discovered cord blood-derived multipotent stem cells (CB-SC) and successfully translated it into the FDA-approved clinical trial. Dr. Zhao invented Stem Cell Educator Therapy for the treatment of type 1 diabetes, type 2 diabetes, and other autoimmune diseases in humans. Currently, his lab is exploring the molecular and cellular mechanisms underlying Stem Cell Educator therapy to improve its clinical efficacy for the treatment of diabetes and autoimmune diseases.