Benjamin Tycko, MD, PhD, is a Senior Scientist in the Department of Biomedical Research and Director of the Division of Genetics & Epigenetics at Hackensack University Medical Center (HUMC).
Our lab has a longstanding research program focusing on genetics and epigenetics in human development and disease. Starting with early studies of genomic imprinting and the function of imprinted genes, our work has evolved into genome-wide and locus-specific profiling of CpG methylation, both net and allele-specific, for disease gene and functional variant discovery and pathway analysis in autoimmune diseases, neuropsychiatric disorders, Down syndrome, and cancers. In this work, we have a major focus on cis- and trans-acting effects of local genomic sequences and chromosomal copy number on DNA methylation patterns. We are also studying combination therapies with epigenetic drugs in mouse models of cancer.