Our Labs

Zakrzewski Lab

Johannes Zakrzewski, MD, is an Associate Scientist at the Center for Discovery and Innovation, Hackensack University Medical Center.

The Zakrzewski laboratory focuses on the development of innovative therapies for the treatment of myeloma, lymphoma, and other cancers, as well as T-cell deficiency. The laboratory provides a platform for interdisciplinary collaboration, integrating oncology, immunology, stem cell biology, bioengineering, and drug development.

Specifically, we are investigating novel strategies for cancer immunotherapy and immunosurveillance by exploiting the endogenous capacity of the thymus to generate genetically modified T cells and harnessing advances in gene therapy and chimeric antigen receptor technology. We are also utilizing immunobioengineering methodologies to achieve thymus-independent T-cell generation. Finally, in collaboration with ImmuneTarget Inc., we are pursuing a drug development program aimed at improving the understanding of NF-κB and oxidative stress as therapeutic targets in multiple myeloma and other cancers. We recently entered the late preclinical stage of development of a novel small molecule inhibitor drug.

Biography

  • 2018-present
    Associate Professor, Georgetown University School of Medicine, Department of Oncology
  • 2018-present
    Georgetown Lombardi Comprehensive Cancer Center,
    Member
  • 2018-present
    Hackensack University Medical Center
    Associate Scientist, Department of Biomedical Research
  • 2018-present
    Weill Cornell Medical College
    Assistant Clinical Professor in Pediatrics
  • 2018
    Memorial Sloan Kettering Cancer Center
    Visiting Investigator
  • 2014-2017
    Weill Cornell Medical College
    Instructor in Pediatrics
  • 2012-2017
    Memorial Sloan Kettering Cancer Center
    Assistant Attending Pediatrician
  • 2010-2012
    Memorial Sloan Kettering Cancer Center
    Clinical Fellow in Pediatric Hematology/Oncology
  • 2008-2010
    SUNY Downstate Medical Center
    Resident in Pediatrics
  • 2007-2009
    Polytechnic Institute of NYU
    Adjunct Professor
  • 2004-2008
    Memorial Sloan Kettering Cancer Center
    Research Fellow in Immunology
  • 2001-2004
    University Hospital of Essen
    Resident in Pediatrics
  • 2000-2001
    Bone Marrow Transplantation Center Idar-Oberstein
    Resident in Pediatrics
  • 1999-2000
    University Hospital of Hamburg-Eppendorf
    Intern in Pediatrics
  • 2000
    Friedrich-Alexander University
    Erlangen-Nuremberg, M.D.