Our Labs
Zakrzewski Lab
Johannes Zakrzewski, MD, is an Associate Scientist at the Center for Discovery and Innovation, Hackensack University Medical Center.
The Zakrzewski laboratory focuses on the development of innovative therapies for the treatment of myeloma, lymphoma, and other cancers, as well as T-cell deficiency. The laboratory provides a platform for interdisciplinary collaboration, integrating oncology, immunology, stem cell biology, bioengineering, and drug development.
Specifically, we are investigating novel strategies for cancer immunotherapy and immunosurveillance by exploiting the endogenous capacity of the thymus to generate genetically modified T cells and harnessing advances in gene therapy and chimeric antigen receptor technology. We are also utilizing immunobioengineering methodologies to achieve thymus-independent T-cell generation. Finally, in collaboration with ImmuneTarget Inc., we are pursuing a drug development program aimed at improving the understanding of NF-κB and oxidative stress as therapeutic targets in multiple myeloma and other cancers. We recently entered the late preclinical stage of development of a novel small molecule inhibitor drug.
Biography
-
2018-presentAssociate Professor, Georgetown University School of Medicine, Department of Oncology
- 2018-present
Georgetown Lombardi Comprehensive Cancer Center,
Member - 2018-present
Hackensack University Medical Center
Associate Scientist, Department of Biomedical Research - 2018-present
Weill Cornell Medical College
Assistant Clinical Professor in Pediatrics - 2018
Memorial Sloan Kettering Cancer Center
Visiting Investigator - 2014-2017
Weill Cornell Medical College
Instructor in Pediatrics - 2012-2017
Memorial Sloan Kettering Cancer Center
Assistant Attending Pediatrician - 2010-2012
Memorial Sloan Kettering Cancer Center
Clinical Fellow in Pediatric Hematology/Oncology - 2008-2010
SUNY Downstate Medical Center
Resident in Pediatrics - 2007-2009
Polytechnic Institute of NYU
Adjunct Professor - 2004-2008
Memorial Sloan Kettering Cancer Center
Research Fellow in Immunology - 2001-2004
University Hospital of Essen
Resident in Pediatrics - 2000-2001
Bone Marrow Transplantation Center Idar-Oberstein
Resident in Pediatrics - 1999-2000
University Hospital of Hamburg-Eppendorf
Intern in Pediatrics - 2000
Friedrich-Alexander University
Erlangen-Nuremberg, M.D.