Jyothi Nagajyothi, Ph.D., is a Member of the Center for Discovery and Innovation.
The long-term research goal of the Nagajyothi lab is to investigate the regulatory mechanisms by which pathological adipocytes and adipose tissue contribute to the pathogenesis, progression and severity of infectious diseases, such as Chagas, tuberculosis and Hansen’s diseases and non-infectious diseases, such as metabolic syndromes and cancer. Her earlier discovery that adipocytes and adipose tissue serve as a reservoir for many pathogens, which can be a risk factor in the development of metabolic syndromes such as obesity and insulin resistance, has opened a link between the pathogenesis of Type 2 Diabetes Mellitus, cardiovascular diseases and severity of acute and chronic infectious diseases, all major causes of death in both developed and developing countries. The Nagajyothi lab has recently discovered that adipogenic adipokine adiponectin acts as a “double-edged sword” in heath and disease. Dr. Nagajyothi’s group is currently investigating the crosstalk mechanism(s) of adipomes and adipokines in regulating immunometabolic pathways in various infectious and non-infectious diseases. In addition, her lab is studying the immunoregulatory effects of diet and metabolic drugs on adipocytes and adipose tissue pathology and its consequences on the progression and severity in chronic diseases.