Shin Lab
Dr. Shin is an assistant member of Hackensack Meridian Health Center for Discovery and Innovation (CDI), an Associate Professor of Medical Sciences and Neurology at the Hackensack Meridian School of Medicine (HMSOM) and a member of the Lombardi Comprehensive Cancer Center (LCCC) of Georgetown University. Before joining CDI, Dr. Shin was an assistant professor of Medical Sciences in the Department of Medicine since 2019. Dr. Shin obtained her BS and MS from South Korea. After she moved to the US, she received her PhD from Emory University where she studied non-cell autonomous contribution in the pathophysiology of Huntington’s disease. As a postdoctoral scientist at UCSF, Dr. Shin conducted research in neurogenetics. Later, she did another postdoctoral research at Columbia University to study the functions of nuclear envelope proteins in liver lipid metabolism and striated muscle diseases.
Selected Publications
Shin JY, Méndez-López I, Wang Y, Hays AP, Tanji K, Lefkowitch JH, Schulze PC, Worman HJ, Dauer WT. Lamina-associated polypeptide-1 interacts with the muscular dystrophy protein emerin and is essential for skeletal muscle maintenance. Dev. Cell 2013;26:591-603
Shin JY, Hernandez-Ono A, Fedotova T, Östlund C, Lee MJ, Gibeley SB, Liang CC, Dauer WT, Ginsberg HN, Worman HJ. Nuclear envelope-localized torsinA-LAP1 complex regulates hepatic VLDL secretion and steatosis. J. Clin. Invest. 2019;130:4885-4900
Östlund C, Hernandez-Ono A, Shin JY. The nuclear envelope in lipid metabolism and pathogenesis of NAFLD. Biology 2020;9:338
Östlund C, Hernandez-Ono A, Turk SJ, Dauer WT, Ginsberg HN, Worman HJ, Shin JY. Intranuclear lipid droplets in hepatocytes deficient in nuclear envelope protein lamina-associated polypeptide 1. J Lipid Res 2022; 63:100277 (Featured on cover page)
Hernandez-Ono A, Zhao Y P, Murray JW, Östlund C, Lee MJ, Dauer WT, Worman HJ*, Ginsberg HN*, Shin JY* Dynamic regulation of hepatic lipid metabolism by torsinA and its activators. JCI insight 2024; 9(3): e175328 [*Co-corresponding authors]