Tycko Lab

Benjamin Tycko, M.D., Ph.D., is a Member of the Center for Discovery and Innovation.

Dr. Tycko’s lab has a longstanding research program focusing on genetics and epigenetics in human development and disease. Starting with early studies of genomic imprinting and the function of imprinted genes, their work has evolved into genome-wide and locus-specific profiling of CpG methylation, both net and allele-specific, for disease gene and functional variant discovery and pathway analysis in autoimmune diseases, neuropsychiatric disorders, Down syndrome, and cancers. In this work, they have a major focus on cis- and trans-acting effects of local genomic sequences and chromosomal copy number on DNA methylation patterns. They are also studying combination therapies with epigenetic drugs in mouse models of cancer.